The availability of high-quality genome sequences of great Optical Disk ape species provides unprecedented opportunities for genomic analyses.Herein, we reviewed the recent progress in evolutionary comparative genomic studies of the existing great ape species, including human, chimpanzee, bonobo, gorilla, and orangutan.We elaborate discovery on evolutionary history, natural selection, structural variations, and new genes of these species, Querectin which is informative for understanding the origin of human-specific phenotypes.